APE NEWS!


Lack of efficacy of using chimps in Research
March 3, 2007, 12:43 pm
Filed under: Chimpanzee Welfare

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Project R&R (Release and Restitution for chimps in US Laboratories) has completed the first of a number of studies to examine the efficacy – or lack thereof – of using chimpanzees in biomedical research and testing. An initial analysis found that chimpanzee studies contributed little, if at all, to tangible human clinical progress and practice.

Between 1995 and 2004 inclusive, 749 studies involving captive chimpanzees were published; 95 were randomly selected and reviewed to determine how often they were cited by subsequent papers.

Of this sample, 49.5% had not been cited at all by other scientific papers. A further 35.8% were cited only by papers that did not describe well-developed prophylactic, diagnostic or therapeutic methods for combating human diseases.

Only 14.7% of our random sample of chimpanzee studies were cited – specifically, 14 papers were cited by 27 subsequent papers. An in-depth analysis of these studies revealed that the chimpanzee experiments had contributed precious little, if anything at all, to the outcome of those papers reporting advances in human clinical practice.

For example, the chimpanzee studies had been conducted concurrently to human studies or to “confirm” previous human investigations; the results from them conflicted with results in other non-human primates or in human trials; the cited chimpanzee studies were peripheral to the human clinical study and/or cited purely as points of information; they illustrated historical findings with no direct relevance to current practice; or, the chimpanzee findings were purely speculative in nature.

Rather, the methods in those 27 papers that were pivotal to the development of human prophylactic, diagnostic or therapeutic methods included: in vitro studies, human clinical and epidemiological studies, molecular assays and methods, and genomic studies.

Specific areas of chimpanzee use in research are currently being systematically reviewed.

“Results are largely ignored, and even those that aren’t do not contribute significantly to human medicine. We must use the millions of dollars chimpanzee research costs more wisely, ethically and humanely and Project R&R will continue to investigate its efficacy – or lack thereof – until it is.” Jarrod Bailey, PhD, Science Director.

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